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    Reader Question: The Bipolar Disorder Antipsychotic and Weight Gain Dilemma

    Here is a question about the antipsychotic Seroquel and weight gain.

    Hi Julie,

    I have been on Seroquel for over 5 years now. I have Bipolar with psychosis. I am tired of the weight gain fight. Seroquel has been very affective in controlling the psychosis which I have frequently. Is there anything that can replace the Seroquel in controlling the psychosis without the weight gain?

    Stinker

    Hi There Stinker,

    Here is a short answer to your question:

    Maybe.

    Here is a longer one:

    Everyone responds differently to antipsychotics.  Many gain wait on them, but some don’t. It’s very, very well documented for example that Zyprexa has an average 20 lb weight gain.  Seroquel, Risperdal, and the other atypical antipsychotics are known for weight gain around the stomach. This leads to a complication called Metabolic Syndrome- I wrote quite a great article on this [ Read More ]





    FDA Approved Bipolar Disorder Drugs

    Here is an interesting list- the FDA (federal drug administration) has to ok a drug for use with bipolar disorder before a drug company can advertise that the drug can be used for bipolar disorder. Here is a list of the approved drugs with their initiation dates. I will write more on this topic in the next few days:

    FDA: Acute Mania        *   1970:  Lithium       *   1973:  Thorazine        *   1995:  Depakote       *   2000:  Zyprexa           *   2003:  Risperdal         *   2004:  Seroquel       *   2004:  Abilify       *   2005:  Geodon       *   2005:  Equetro (Tegretol)     FDA: Acute Bipolar Depression             *  2004: Symbyax                  (Prozac-Zyprexa combo)          *  2007: Seroquel

    FDA: Maintenance (for use in managing bipolar disorder in general)                *  1974:  Lithium: both          *  2003:  Lamictal:                          depression          *  2004:  Zyprexa: both          *  2005:  Abilify: both

    This list can be a bit confusing- especially [ Read More ]





    Bipolar Disorder Medications: What is Zyprexa? (Olanzapine)

     Zyprexa, also known as Olanzapine is an anti psychotic drug (also known as a neuroleptic) used to treat psychosis and psychotic mania.

    It’s called an atypical antipsychotic as it is a new class of drugs with less side effects that the old anti-psychotics such as Thorazine and Haldol. Zyprexa is known for weight gain- an average of 20 pounds per person, but I definitely know people who don’t gain weight at all.

    Zyprexa is used to treat bipolar disorder mania and psychosis – (and schizophrenia.)

    I have seen it work miracles on people who are very ill.  It’s hard to find a balance between the benefits of the drug and the side effects- but for many, the benefits are what matters. I have a friend who was on the drug for two years to keep her mania and psychosis in check. It definitely kept her out of the hospital- but she felt over drugged and [ Read More ]





    Bipolar Disorder and Pristiq (desvenlafaxine): a new antidepressant

    I recently opened a magazine and saw an antidepressant (Pristiq) I had never heard of- so I asked my coauthor Dr. John Preston to explain the mistique of Pristiq!

    Hi…Pristiq (desvenlafaxine)is a clone of Effexor…I like it because the starting dose is often the therapeutic dose (50 mg)…with Effexor you had to start low (37.5 mg) and gradually increase the dose (often up to 150-300 mg)…also Pristiq has somewhat less nausea than Effexor….but like all antidepressants is absolutely can cause mania… John 

    **And as we all know… people with bipolar disorder can’t take antidepressants alone- and if they do take them- it needs to be in combination with a mood stabilizer such as lithium, depakote or tegretol!  Pristiq sounds like a resort! Who names these things!  Julie  

    PS: If you view this blog from amazon.com, you can see the whole blog at www.bipolarhappens.com/bhblog

    [ Read More ]